Pharma R&D Today

Ideas and Insight supporting all stages of Drug Discovery & Development

Select category
Search this blog
Helena Deus

Helena Deus

Senior Technology Researcher

Connect with Helena Deus on LinkedIn

About the author: I’m a biologist by training and was brought into Elsevier to bridge the work we do in life sciences and healthcare with machine learning. One of the models I’m working on will be able to identify whether a sentence in an abstract is a result, method, hypothesis or a goal. This is important to compare papers with each other and understand the validity of the science. Non-reproducibility is a big problem, which has enormous implications for drug companies, who can’t always trust new research coming out of academia and often have to do studies all over again. If machine learning could improve the quality of science, this would have huge implications on the price and speed of drug manufacturing.

Posts by Helena Deus

Drug Repurposing for SARS-CoV-2 Using Network Polypharmacological Approach

Posted on June 9th, 2020 in COVID-19

Drug development is a multidisciplinary field that requires a drug to successfully pass through different stages — from chemical design to biological experimentation on cells and animals, and finally three phases of human clinical trials — before being approved by the FDA for clinical administration. However, following such a path would not be feasible under circumstances where rapid discoveries are required, such as in the case of the current SARS-CoV-2 outbreak. Hence, repurpose of already approved FDA drugs could help in such circumstances, which can save effort, time and money.


Navigating the Virus Regulation Pathway through Text Mining and Knowledge Graph

Posted on May 20th, 2020 in COVID-19

A computer virus exploits the operating system of a computer to replicate (copy itself) and send copies of itself to other computers in the network. In the same manner, a human virus manipulates the cell’s “operating system,” managed by cellular proteins, to replicate and infect other cells in the body. Specifically, the virus forces the cell to terminate its ongoing operations and start making copies of its viral particles by controlling the expression and behavior of pre-existing proteins in the cell.