Pharma R&D Today

Ideas and Insight supporting all stages of Drug Discovery & Development

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Paul Dockerty

Paul Dockerty

Customer Engagement Manager – Professional Services

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About the author: Dr. Paul Dockerty has a Pharmacist degree from the University of Rouen, France, a M.S degree in Chemistry from the University Paris Descartes, France and a Ph.D in Chemical Biology from the University of Groningen, The Netherlands where he focused on the development of chemical probes based on a enol-carbamate scaffold. He works now as a Customer Engagement Manager in the Professional Services group at Elsevier and is responsible for supporting pharmaceutical customers in their digitalization journey.

Posts by Paul Dockerty

The power of similarities to accelerate antiviral development for COVID-19

Posted on January 11th, 2022 in COVID-19

In April 2020, I wrote a blog post entitled “Exploiting similarities between SARS-CoV-2 and other viruses to accelerate vaccine and therapy development,” where I described research areas leveraging genetic and phenotypic similarities between SARS-CoV-2 and other known viruses. In my quest to find relevant data, I used Reaxys Medicinal Chemistry to generate a list of substances that interact with enterovirus 3C proteases, a target showing striking similarities with the main proteases of SARS-CoV and SARS-CoV-2. A set of interesting derivatives using a cyanohydrin as an anchor group caught my attention.1 Interestingly, Pfizer used the cyano warhead a few months later to design their protease inhibitor (PF-07321332). Pfizer’s antiviral forms a complex structure with SARS-CoV-2 Mpro, demonstrating the efficacy of the cyano warhead to form a covalent bond with the cysteine residue at the active site.2

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Workforce Upskilling in Pharma R&D

Posted on February 5th, 2021 in Pharma R&D

There is comfort in habits. There is comfort in the familiar. In normal times, change usually only occurs at a relatively slow pace. When we update one of our cell phone applications, it usually takes a while before we adopt this new fancy functionality and take advantage of it. After all, it has been working well for us even before the update, right? So why change if things are fine? Even in our work, we find comfort in routines and repeating tasks that we feel we are good at. But there are changes that we cannot hide from.

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Readying Your Workforce for Digital Transformation

Posted on June 23rd, 2020 in Pharma R&D

Seeing it as key to innovation and competitive advantage, many businesses in the life sciences are learning to embrace digital transformation these days—in fact, with good reason, most view it as necessary for survival. But whether or not the process of adopting rapidly-evolving digital-age technologies will actually result in business success can really depend on how you do it.

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A Systems Thinking Approach for Pharma

Posted on May 21st, 2020 in Chemistry

Systems thinking asks scientists to look at the bigger picture and take a more holistic approach to their work. Systems thinkers consider how their field of study might relate to other disciplines, and how their research might inform or benefit from the broader knowledge stream. 

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