Pharma R&D Today

Ideas and Insight supporting all stages of Drug Discovery & Development

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At the leading edge of an innovation hotspot: predictive reaction modeling

Posted on September 8th, 2021 by

Indisputably, a surge in predictive machine learning models to support synthetic chemistry has galvanized a movement to make these tools effective R&D solutions. Reaxys has been part of this innovation journey from the beginning. Today, Reaxys includes an award-winning Predictive Retrosynthesis solution that merges deep neural networks trained on Reaxys data with a Monte Carlo tree search to quickly discover promising candidate routes. Users explore these routes and new synthetic spaces via an intuitive interface that links to Reaxys content on commercial availability and accelerates design-make-test-analyze (DMTA) cycles.

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Companies pledge to become net zero by 2040

Posted on August 31st, 2021 by

The Intergovernmental Panel on Climate Change (IPCC) just released a special report on the impacts of climate change, and the findings suggest a very concerning picture of the future if greenhouse gas emissions continue at the current rate. The drastic changes in the weather, driving everything from wildfires to drought, are already giving us a preview of an increasingly turbulent future – and the knock-on effects can be seen in resulting crises like the large-scale loss of crops and homes.

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Accelerating synthetic chemistry with a predictive retrosynthesis solution

Posted on August 12th, 2021 by

In most aspects of life, we think of “endless possibilities” as a good thing. But in science, the wealth of possibilities can be daunting. Pharmaceutical researchers typically start with a disease that they want to tackle, find a target, and then try to identify compounds which interact with that target. There may be around 200-300 drug candidates per project, and synthesis planning and execution usually takes four to eight weeks per drug candidate. This process requires many chemists and a huge, costly effort to proceed.

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How the Elsevier Foundation partnerships support sustainable development

Posted on July 7th, 2021 by

OWSD-Elsevier Foundation Awards for Early-Career Women Scientists in the Developing World award winners

Each year, the Elsevier Foundation gives over $1 million to an array of non-profit organizations. This support has gone to promising collaborations, STEM initiatives, leadership programs, technology platforms, early to mid-career scholars and more.

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