Pharma R&D Today

Ideas and Insight supporting all stages of Drug Discovery & Development

Select category
Search this blog

The Five Most-Talked about Zika Articles in 2017

Posted on October 23rd, 2017 by in Pharma R&D

Mosquito Zika

A widespread outbreak in 2015 had people across the globe concerned about Zika (ZIKV), an infectious disease mainly spread through mosquito bites. In 2016 we took a look at some of the top scientific research about the virus being shared online. 

While the Zika emergency ended late last year, the virus remains a serious threat in numerous countries. Pregnant women (or those trying to become pregnant) are especially concerned about the virus due to its connection to severe birth defects, including microcephaly. Adults can also be affected, as infections have been linked to Guillain–Barré syndrome. Fortunately, scientists have been laboring to better understand Zika and to find ways to combat it.

Here are the latest five most popular research articles on the topic of the Zika virus:

Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease
Cell, Justin M. Richner et al., Volume 170, Issue 2, 13 July 2017, Pages 273–283.e12
Though several viral vaccine platforms had been established in animals, researchers found none had yet addressed the pressing concern of protection during pregnancy. So this study tested two vaccine platforms to see if they could protect against transmission to a fetus.

Prospects for a Zika Virus Vaccine
Immunity, Dan H. Barouch et al., Volume 46, Issue 2, 21 February 2017, Pages 176–182
In this review of the current state of vaccine development for ZIKV, different vaccination strategies and some of the challenges facing clinical evaluations of Zika vaccine candidates are discussed.

Differential Responses of Human Fetal Brain Neural Stem Cells to Zika Virus Infection
Stem Cell Reports, Erica L.McGrath et al., Volume 8, Issue 3, 14 March 2017, Pages 715-727
This study confirms that an Asian-lineage ZIKV strain infects primary hNSCs and demonstrates a cell-strain-dependent response of hNSCs to ZIKV infection.

Outbreak of Zika virus infection in Singapore: an epidemiological, entomological, virological, and clinical analysis
The Lancet Infectious Diseases, The Singapore Zika Study Group, Volume 17, Issue 8, August 2017, Pages 813-821
The Singapore Zika Study Group presents a comprehensive report examining the nation’s response to an Asian outbreak of the Zika virus infection that was detected in Singapore in August 2016.

25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model
Immunity,  Chunfeng Li et al., Volume 46, Issue 3, 21 March 2017, Pages 446-456
This article demonstrates how CH25H and its enzymatic product, 25HC, was found to inhibit ZIKV entry in vitro, that 25HC prevents ZIKV infection in human cortical organoids, and that 25HC protects fetal mice from microcephaly caused by ZIKV infection.


All opinions shared in this post are the author’s own.

R&D Solutions for Pharma & Life Sciences

We're happy to discuss your needs and show you how Elsevier's Solution can help.

Contact Sales