Pharma R&D Today

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SARS-CoV-2 Vaccine Candidates In or Nearing Clinical Trials

Posted on May 6th, 2020 by in COVID-19

The number of vaccines in the pipeline to battle the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has reached to >70 candidates [1,2]. Many different vaccination strategies are being tested, even a noncoronavirus-specific candidate (Bacille Calmette-Guerin vaccine) [2,3] is being investigated because of its potential to promote a less inflammatory immune response to respiratory pathogens [2]. However, a SARS-Cov-2–specific vaccine will likely be a better strategy.

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Nucleic Acid–Based Vaccines in Development for SARS-CoV-2

Posted on May 1st, 2020 by in COVID-19

With the coronavirus disease 2019 (COVID-19) case and death count climbing [1] despite multiple industry shutdowns and extensive social distancing efforts, it has become clear that a vaccine is required to control the spread of the COVID-19 causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many different researchers, institutes and companies specializing in vaccine development across the world have entered the race and announced a candidate, resulting in an astonishingly large number (>70) of vaccines in the pipeline [2,3].

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Mathematical modeling the emergence and spread of new pathogens: Insight for SARS-CoV-2 and other similar viruses

Posted on April 24th, 2020 by in COVID-19

Knowing if and how rapidly an emerging pathogen will spread through a population enables public health officials to make well-informed decisions to protect the public. Mathematical modeling can provide them this means to predict pathogen spread, but modeling previously unheard of pathogens, like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is challenging.

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Exploiting similarities between SARS-CoV-2 and other viruses to accelerate vaccine and therapy development

Posted on April 17th, 2020 by in COVID-19

Coronavirus disease 19 (COVID-19) is now present in 230 countries, areas or territories around the world. As of April 15, 2020, the World Health Organization has reported 117,021 deaths [1]. Researchers across the globe are collaborating to develop antivirals and vaccines. In this context, understanding the vast amount of data published on SARS-CoV and other viruses is key to tackling the challenge of containing the 2019 novel coronavirus (SARS-CoV-2).

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