Pharma R&D Today

Ideas and Insight supporting all stages of Drug Discovery & Development

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5 Ways RWE is Fueling the Fight Against COVID-19

Posted on June 19th, 2020 by in COVID-19

As we discussed in an earlier blog post, real-world evidence can bring value to every stage of the drug life cycle, from early discovery to post-market. Now, as the worldwide research community continues to battle the COVID-19 pandemic, we are also discovering how real-world data and real-world evidence have something to offer in these efforts as well.

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The FAIR Toolkit Helps Researchers with Data Challenges

Posted on June 16th, 2020 by in Pharma R&D

Since the spread of COVID-19 was first reported, researchers of all types have mobilized to meet the challenges its causative agent, SARS-CoV-2, presents to the world. Data scientists in particular have been quick to apply their expertise to the problems of identifying, tracking and predicting outbreaks; diagnosing COVID-19; identifying infected individuals and detecting non-compliance with virus countermeasures; discovering new therapeutic interventions or repurposing existing ones; and searching for a safe, effective vaccine.

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Drug Repurposing for SARS-CoV-2 Using Network Polypharmacological Approach

Posted on June 9th, 2020 by in COVID-19

Drug development is a multidisciplinary field that requires a drug to successfully pass through different stages — from chemical design to biological experimentation on cells and animals, and finally three phases of human clinical trials — before being approved by the FDA for clinical administration. However, following such a path would not be feasible under circumstances where rapid discoveries are required, such as in the case of the current SARS-CoV-2 outbreak. Hence, repurpose of already approved FDA drugs could help in such circumstances, which can save effort, time and money.

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Navigating the Virus Regulation Pathway through Text Mining and Knowledge Graph

Posted on May 20th, 2020 by in COVID-19

A computer virus exploits the operating system of a computer to replicate (copy itself) and send copies of itself to other computers in the network. In the same manner, a human virus manipulates the cell’s “operating system,” managed by cellular proteins, to replicate and infect other cells in the body. Specifically, the virus forces the cell to terminate its ongoing operations and start making copies of its viral particles by controlling the expression and behavior of pre-existing proteins in the cell.

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