Pharma R&D Today

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Drug Repurposing for SARS-CoV-2 Using Network Polypharmacological Approach

Posted on June 9th, 2020 by in COVID-19

Drug development is a multidisciplinary field that requires a drug to successfully pass through different stages — from chemical design to biological experimentation on cells and animals, and finally three phases of human clinical trials — before being approved by the FDA for clinical administration. However, following such a path would not be feasible under circumstances where rapid discoveries are required, such as in the case of the current SARS-CoV-2 outbreak. Hence, repurpose of already approved FDA drugs could help in such circumstances, which can save effort, time and money.

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Navigating the Virus Regulation Pathway through Text Mining and Knowledge Graph

Posted on May 20th, 2020 by in COVID-19

A computer virus exploits the operating system of a computer to replicate (copy itself) and send copies of itself to other computers in the network. In the same manner, a human virus manipulates the cell’s “operating system,” managed by cellular proteins, to replicate and infect other cells in the body. Specifically, the virus forces the cell to terminate its ongoing operations and start making copies of its viral particles by controlling the expression and behavior of pre-existing proteins in the cell.

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Modulators, Biomarkers and Potential Treatments for COVID-19

Posted on May 14th, 2020 by in COVID-19

With the trend of open science, people are becoming more receptive to the idea of sharing data and using what is already accessible. Particularly for researchers, there is so much data available that can answer questions and develop hypotheses and strategies that could save effort, time and money. This is mainly important in cases where rapid discoveries are required, such as in the case of the current COVID-19 outbreak.

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SARS-CoV-2 Vaccine Candidates In or Nearing Clinical Trials

Posted on May 6th, 2020 by in COVID-19

The number of vaccines in the pipeline to battle the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has reached to >70 candidates [1,2]. Many different vaccination strategies are being tested, even a noncoronavirus-specific candidate (Bacille Calmette-Guerin vaccine) [2,3] is being investigated because of its potential to promote a less inflammatory immune response to respiratory pathogens [2]. However, a SARS-Cov-2–specific vaccine will likely be a better strategy.

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