Pharma R&D Today

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Drug Repurposing for SARS-CoV-2 Using Network Polypharmacological Approach

Posted on June 9th, 2020 by in COVID-19

Drug development is a multidisciplinary field that requires a drug to successfully pass through different stages — from chemical design to biological experimentation on cells and animals, and finally three phases of human clinical trials — before being approved by the FDA for clinical administration. However, following such a path would not be feasible under circumstances where rapid discoveries are required, such as in the case of the current SARS-CoV-2 outbreak. Hence, repurpose of already approved FDA drugs could help in such circumstances, which can save effort, time and money.

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Modulators, Biomarkers and Potential Treatments for COVID-19

Posted on May 14th, 2020 by in COVID-19

With the trend of open science, people are becoming more receptive to the idea of sharing data and using what is already accessible. Particularly for researchers, there is so much data available that can answer questions and develop hypotheses and strategies that could save effort, time and money. This is mainly important in cases where rapid discoveries are required, such as in the case of the current COVID-19 outbreak.

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Five drug development strategies to combat 2019 novel coronavirus

Posted on April 15th, 2020 by in COVID-19

This article was originally published on Feb 28, 2020, and has been updated on Apr 13, 2020.

Coronavirus disease 19 (COVID-19) has rapidly spread from its starting point in Wuhan, China. As of February 23, 2020, a total of 32 countries and territories have reported 78,811 cases (98% in China) and 2462 deaths [1]. The international scientific community is in a race against time. Researchers across the globe are collaborating to develop antivirals and vaccines to contain the spread of 2019 novel coronavirus (SARS-CoV-2).

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Integration and visualization of COVID-19 molecular mechanisms using Pathway Studio

Posted on April 6th, 2020 by in COVID-19

Integrating the rich information from multi-omics data has been a popular approach to drugs discovery and development against novel 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To facilitate the integrative analysis and power the global researchers, we have constructed various models that contain biomedical pathways information for SARS-CoV and SARS-CoV-2. Now they are available for public access.

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