Pharma R&D Today

Ideas and Insight supporting all stages of Drug Discovery & Development

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At the leading edge of an innovation hotspot: predictive reaction modeling

Posted on September 8th, 2021 by in Chemistry

Indisputably, a surge in predictive machine learning models to support synthetic chemistry has galvanized a movement to make these tools effective R&D solutions. Reaxys has been part of this innovation journey from the beginning. Today, Reaxys includes an award-winning Predictive Retrosynthesis solution that merges deep neural networks trained on Reaxys data with a Monte Carlo tree search to quickly discover promising candidate routes. Users explore these routes and new synthetic spaces via an intuitive interface that links to Reaxys content on commercial availability and accelerates design-make-test-analyze (DMTA) cycles.

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Accelerating synthetic chemistry with a predictive retrosynthesis solution

Posted on August 12th, 2021 by in AI & Data

In most aspects of life, we think of “endless possibilities” as a good thing. But in science, the wealth of possibilities can be daunting. Pharmaceutical researchers typically start with a disease that they want to tackle, find a target, and then try to identify compounds which interact with that target. There may be around 200-300 drug candidates per project, and synthesis planning and execution usually takes four to eight weeks per drug candidate. This process requires many chemists and a huge, costly effort to proceed.

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Technology and empathy help make remote working a success for Elsevier

Posted on July 29th, 2021 by in Pharma R&D

We at Elsevier were pleased to be one of five companies recognized for their ability to keep remote workers rooted in company culture in this recent Comparably article. Like many organizations during the pandemic, we had to quickly adapt to remote working on a large scale for our international workforce. As the article notes, “Elsevier took an empathetic and pragmatic approach in supporting its people and its customers and rapidly harnessed technology to work from home.”

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Expert Forum Examines the Patent Content Expansion Plan for Reaxys

Posted on May 21st, 2021 by in Chemistry

User feedback is instrumental to the evolution of Reaxys. Not only in articulating what works and what is missing, but also in guiding the direction of newly developed capabilities to meet user information needs.

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