Pharma R&D Today

A Systems Thinking Approach for Pharma

Posted on May 21st, 2020 by Paul Dockerty

Systems thinking asks scientists to look at the bigger picture and take a more holistic approach to their work. Systems thinkers consider how their field of study might relate to other disciplines, and how their research might inform or benefit from the broader knowledge stream. 

Navigating the Virus Regulation Pathway through Text Mining and Knowledge Graph

Posted on May 20th, 2020 by Helena Deus

A computer virus exploits the operating system of a computer to replicate (copy itself) and send copies of itself to other computers in the network. In the same manner, a human virus manipulates the cell’s “operating system,” managed by cellular proteins, to replicate and infect other cells in the body. Specifically, the virus forces the cell to terminate its ongoing operations and start making copies of its viral particles by controlling the expression and behavior of pre-existing proteins in the cell.

Global networks form to take on the problem of drug-induced liver injury (DILI)

Posted on May 20th, 2020 by Xuanyan Xu

Drug-induced liver injury (DILI), which is one of the top causes of liver failure in the United States [1], is an adverse reaction that can be caused by a significant number of medications. DILI can be fatal and is not only a major concern post-market, but also during drug development as it is the top safety-related reason for late-stage clinical trial failure.

Modulators, Biomarkers and Potential Treatments for COVID-19

Posted on May 14th, 2020 by Yapeng Zhang

With the trend of open science, people are becoming more receptive to the idea of sharing data and using what is already accessible. Particularly for researchers, there is so much data available that can answer questions and develop hypotheses and strategies that could save effort, time and money. This is mainly important in cases where rapid discoveries are required, such as in the case of the current COVID-19 outbreak.

Partnering to identify repurposing candidates for chronic pancreatitis

Posted on May 12th, 2020 by Ani Marrs

Take a look at this infographic demonstrating how leveraging Entellect and collaborating with three partners led to a datathon that delivered four potential repurposing candidates in just 60 days.

Reaxys database search now available from Marvin

Posted on May 8th, 2020 by Elena Herzog

The number of chemical reactions and substances platforms like Reaxys has grown exponentially in recent years. The challenge for chemical information tools has shifted from exploration of new horizons in the chemistry space to refining and filtering structure and reaction searches to find the exact substances or reactions that one is seeking. As the next step in a long-term collaboration, Reaxys is now connected with ChemAxon’s flagship cheminformatics solution Marvin, making complex structure searches faster and easier, and directly accessible from the desktop application.

About this Blog

The Elsevier Pharma R&D blog provides insight and opinion on topics related to pharmaceutical research and development, namely: big data, target identification, new drug discovery, drug safety monitoring, risk mitigation and regulatory compliance. We serve the community of chemists, scientists, drug safety specialists, educators and students interested in pharmaceutical R&D.

Editor’s note: The views and opinions expressed are those of the author and do not necessarily reflect the views of Elsevier,  its affiliates and sponsors or its parent company, Reed Elsevier.