Pharma R&D Today

Bringing Scalability Into Chemistry Modeling

Posted on November 18th, 2020 by Ani Marrs

Synthetic chemistry has been with us for centuries, but it is now entering a new frontier. Big data, AI and machine learning are unlocking a predictive power that is transforming the conceptualization and optimization of synthetic routes.

International Life Science Awards Recognize Reaxys

Posted on November 16th, 2020 by Xuanyan Xu

The International Life Sciences Awards, an initiative from Global Health & Pharma Magazine (GHP) that is now in its fifth year, recognizes industry innovators – and this year that has included honoring Reaxys as an innovation leader by awarding it the Best Chemistry Predictive Analytics Specialists 2020 for its best-in-class Predictive Retrosynthesis software.

New Coronavirus Advisory Team Announced

Posted on November 16th, 2020 by Xuanyan Xu

Wasting no time to start enacting his forthcoming administration’s plan for tackling COVID-19, new president-elect of the United States, Joe Biden, has unveiled his coronavirus advisory team. “Dealing with the coronavirus pandemic is one of the most important battles our administration will face, and I will be informed by science and by experts,” he stated.

BCG – COVID-19 Hackathon Challenge Now Extended Through End of Year

Posted on October 23rd, 2020 by Ani Marrs

A renewed interest in whether the BCG vaccine (for tuberculosis) could also have an application for COVID-19 has been on the rise, as evidenced by this recent Cell publication, the University of Exeter’s involvement in the BRACE Trial and ongoing general press coverage. Furthermore, the list of clinical trials focusing on this area is continuing to grow (and is available here).

Model-based Strategy to Guide the Choice of Clinical Doses for ADC

Posted on October 14th, 2020 by Xuanyan Xu

Chemotherapy has been a powerful method for fighting cancer for decades. One of the most effective therapies available, it is also known for weakening the patient and causing harsh side effects like pain, nausea, and hair loss. This is because in its zeal to attack cancer cells, chemo also kills healthy cells.

How DNA-encoded Libraries Boost Drug Discovery

Posted on October 7th, 2020 by Xuanyan Xu

DNA-encoded libraries (DELs) have been gaining a lot of traction in hit finding and drug discovery in recent years. Regarded by some as a truly revolutionary advance in chemistry, a DEL is a mixture of millions of small molecules in which each molecule is conjugated to a DNA-oligomer that encodes its chemical structure. The mixture can be stored in a simple test tube.

About this Blog

The Elsevier Pharma R&D blog provides insight and opinion on topics related to pharmaceutical research and development, namely: big data, target identification, new drug discovery, drug safety monitoring, risk mitigation and regulatory compliance. We serve the community of chemists, scientists, drug safety specialists, educators and students interested in pharmaceutical R&D.

Editor’s note: The views and opinions expressed are those of the author and do not necessarily reflect the views of Elsevier,  its affiliates and sponsors or its parent company, Reed Elsevier.