Pharma R&D Today

More Drugs, Fewer Patients: Limits of Precision Medicine

Posted on November 9th, 2015 by Thibault Geoui

A number of targeted medications that are highly effective for a subgroup of patients with a particular disease have emerged in the last decade. These are often needed alternatives to debilitating therapies with uncertain outcomes. The small number of patients that benefit from such therapies, however, may pose a serious challenge looking into the future. (more…)

Reaxys: Then & Now

Posted on October 30th, 2015 by Thibault Geoui

Reaxys, an online chemistry research solution from Reed Elsevier Properties SA, improves R&D productivity by delivering experimental facts on chemical structures, properties, reactions and procedures. It’s been around since 2009, but what came before it directly shaped what Reaxys was, what it is today and what it will be in the future. Discover the history of Reaxys. (more…)

Ensuring the Safety of New Antipsychotics

Posted on October 30th, 2015 by Thibault Geoui

Antipsychotics have complex pharmacological profiles and adverse events are common with long-term use. New or optimized drugs with better safety profiles are desirable. The best way to get information on a new compound that has potential as an antipsychotic is to use in silico profiling to compare it to existing drugs, as described in this new paper.

Read all about drug safety of new antipsychotics.

Speeding up Science: How We Can Stop the Decline of Drug Production as Scientific Information Increases

Posted on October 28th, 2015 by Thibault Geoui

Every 9 years, scientific output is doubling and more information is being made available to the world’s top scientists. Contrary to common sense and public opinion, for every 1 billion invested in drug development, the number of drugs approved has been halved every 9 years, and approximately 70% of drugs sold in the US today are generics. (more…)

Using Intelligent and Connected Taxonomies to Power Insightful Reasearch

Posted on October 27th, 2015 by Thibault Geoui

Information is useful only when it can be found. Taxonomies offer obvious organizational benefits, but their impact on database usability is far-reaching.
Read an excerpt from the Elsevier whitepaper, The Means to Use Information, to discover how to maximize taxonomies and learn how to utilize intelligent and connected taxonomies to take your insightful research to the next level. (more…)

Pharmacovigilance: Rethinking Literature Monitoring and Review

Posted on October 27th, 2015 by Neal Katz

Pharmacovigilance is defined as “the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug-related problems.” Under that umbrella, government agencies in the United States, the European Union and other parts of the world have developed diverse and increasingly complex regulatory requirements. (more…)

About this Blog

The Elsevier Pharma R&D blog provides insight and opinion on topics related to pharmaceutical research and development, namely: big data, target identification, new drug discovery, drug safety monitoring, risk mitigation and regulatory compliance. We serve the community of chemists, scientists, drug safety specialists, educators and students interested in pharmaceutical R&D.

Editor’s note: The views and opinions expressed are those of the author and do not necessarily reflect the views of Elsevier,  its affiliates and sponsors or its parent company, Reed Elsevier.