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Top 10 Most Talked-About Articles on Zika

Posted on September 21st, 2016 by in Pharma R&D


The Zika virus (ZIKV) has been linked to severe birth defects, causing fear of the virus around the globe. As people, particularly pregnant women, take measures to protect themselves from exposure to mosquitos that might be carrying Zika, scientists are working hard to better understand the nature of the virus and its transmission so that they can develop vaccines and treatments to combat it. Here is a list of some of the most talked about academic Zika articles across social media, blogs and news sites.

  1. Cell Host & Microbe – “Zika Virus Targets Different Primary Human Placental Cells, Suggesting Two Routes for Vertical Transmission”  How the Zika virus is transmitted from mother to fetus has been unclear, but this study tries to determine exactly how the infection spreads.
  2. Cell – “Structural Basis of Zika Virus-Specific Antibody Protection” The findings presented in this paper point to a possible path for developing prophylactic antibodies to be used during pregnancy or for designing certain types of vaccines against ZIKV.
  3. Cell Reports – “Broadly Neutralizing Activity of Zika Virus-Immune Sera Identifies a Single Viral Serotype” Among other things, this study reveals that strain selection may not be a critical parameter in developing a Zika vaccine.
  4. Lancet Infectious Diseases – “Zika virus in the female genital tract” This case study reports the discovery of Zika in a female patient’s genital tract and suggests its findings raise the possibility that a woman could become a chronic carrier of the Zika virus.
  5. The Lancet – “Association between Zika virus and microcephaly in French Polynesia, 2013–15: a retrospective study” An investigation into the Zika outbreak in the South Pacific provides an estimate of the risk of microcephaly for fetuses whose mothers have the virus.
  6. Developmental Biology – “Redeployment of a conserved gene regulatory network during Aedes aegypti development” Highlights of this study include a report of a novel mode of GRN evolution mediating developmental system drift.
  7. The Lancet – “El Niño and climate change—contributing factors in the dispersal of Zika virus in the Americas?” In this letter, the argument is made that extreme weather conditions could have played a significant role in Brazil’s Zika outbreak.
  8. The Lancet – “Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation” This study examines the babies born right after the microcephaly epidemic was first reported in Brazil in late 2015.
  9. Epidemics: The Journal of Infectious Disease Dynamics – “A theoretical estimate of the risk of microcephaly during pregnancy with Zika virus infection” An integral equation model and a backcalculation technique is used to analyze epidemiological datasets of reported dengue-like illness and microcephaly in a region of Brazil in 2015.
  10. Cell Host & Microbe – “A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection” There isn’t an approved vaccine for ZIKV yet, but this study looked at hundreds of drugs and identified several that reduced Zika infection across multiple cell types and are therefore good candidates to be tested in clinical studies.

Discover all these articles and more on ScienceDirect. Enable better understanding of biological processes underlying disease progression and treatment response with Pathway Studio.




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