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Mathematical modeling the emergence and spread of new pathogens: Insight for SARS-CoV-2 and other similar viruses

Posted on April 24th, 2020 by in COVID-19

Knowing if and how rapidly an emerging pathogen will spread through a population enables public health officials to make well-informed decisions to protect the public. Mathematical modeling can provide them this means to predict pathogen spread, but modeling previously unheard of pathogens, like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is challenging.

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Exploiting similarities between SARS-CoV-2 and other viruses to accelerate vaccine and therapy development

Posted on April 17th, 2020 by in COVID-19

Coronavirus disease 19 (COVID-19) is now present in 230 countries, areas or territories around the world. As of April 15, 2020, the World Health Organization has reported 117,021 deaths [1]. Researchers across the globe are collaborating to develop antivirals and vaccines. In this context, understanding the vast amount of data published on SARS-CoV and other viruses is key to tackling the challenge of containing the 2019 novel coronavirus (SARS-CoV-2).

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Hydroxychloroquine and the Coronavirus: Connecting the Dots Through the Biology Knowledge Graph

Posted on April 16th, 2020 by in COVID-19

It would be hard to miss the current interest in finding effective treatment for COVID-19. In this regard, the combination of hydroxychloroquine (HCQ) with azithromycin is getting a great deal of attention. HCQ, sold under the brand name Plaquenil, is a well-known anti-malarial drug, while azithromycin is a common antibiotic that is usually used for the treatment of strep throat (the widely used Zithromax, Z-Pak).

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Five drug development strategies to combat 2019 novel coronavirus

Posted on April 15th, 2020 by in COVID-19

This article was originally published on Feb 28, 2020, and has been updated on Apr 13, 2020.

Coronavirus disease 19 (COVID-19) has rapidly spread from its starting point in Wuhan, China. As of February 23, 2020, a total of 32 countries and territories have reported 78,811 cases (98% in China) and 2462 deaths [1]. The international scientific community is in a race against time. Researchers across the globe are collaborating to develop antivirals and vaccines to contain the spread of 2019 novel coronavirus (SARS-CoV-2).

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